ABSTRACT

The purpose of this study was to control infectious diseases by discovering new antibiotic compounds. To achieve this goal, series of carboxamide derivatives of moxifloxacin has been synthesized. The structures of synthesized derivatives have been establishedthrough spectroscopic method that was UV, IR, H1NMR and Mass-spectra. In present work, we focused on carboxylic group (C-3position) of drug for derivatization. Screening of their antimicrobial activities have been systematically carried out against various Gram-positive, Gram-negative organisms and fungi in comparison with parent drugs. Statistical analysis has been carried out by SPSS and results were analyses by applying one way ANOVA. The biological data shows that the prepared derivatives have good activities against B. subtilis and P. aeruginosa. Furthermore, all derivatives showed excellent result against F. solani and T. rubrum. So, we can conclude that, the developed novel compounds have higher antifungal and antibacterial activities as related to standard drug. Keywords: Moxifloxacin, carboxamide derivatives, biological evaluation, one-way ANOVA

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https://doi.org/10.31032/IJBPAS/2019/8.5.4709