BACKGROUND: Leukemia is most prevalent in children and is the second most common
reason of mortality in children aged between 1-14 years. It accounts for every 3 of the 10 cancers
diagnosed in children aged below 15 years. Exact causes of leukemia are still unknown.
Evidence suggests certain cellular, genetic factors and biochemical alterations are responsible for
the disease
MATERIAL AND METHOD: Total 70 individuals were taken in present study in which 50
included in positive control and other 20 were included in negative control group. The 5 ml
blood sample was collected from each individual to perform following biomarkers through
specific respective protocols. Antioxidants and MDA assessed through specterophometery method but the levels of S ferritin, S Fe, IL-6, hs-CRP and TNF-? were determined through
commercially available ELIZA kits.
RESULTS: The levels of MDA (3.80±1.14), IL-6 (6.73±0.84) TNF-alpha (31.67±4.47), S Fe
(138.16±19.06) and S ferritin (186.29±69.14) were increased in subjects as compared to normal
persons (1.43±0.36), (5.64±0.51), (29.90±1.142), (85.28±3.26) and (105.57±1.95) respectively.
The levels of antioxidant like SOD (0.09±0.091), CAT (2.25±1.18), GSH (4.35±1.62), GSH-Px
(6.61±0.37) were decrease in leukemic patients but the levels of GSH-Pr (4.39±1.59) increased
in same individuals as compared to normal control group (0.49±0.14), (3.95±0.81), (9.79±1.22),
(8.22±0.69), and (1.47±0.22) respectively. Levels of GGT (58.75±8.56) and hs-CRP
(1.48±0.301) were increased in leukemic patients as compared to control group (43.12±6.82),
(1.043±0.023).
CONCLUSION: Leukemia are neoplastic disorder, there are several cellular and genetic
reasons involved in the progression of the disease. Out of which NK cells reactivity and
defective mode of action may contribute as the reason for the leukemia in number of patients.
Our study concludes and signifies the importance of antioxidant profile in the progression of
disease. As in the subjects having, the disorder showed significant decrease in their antioxidant
levels such SOD, GSH, CAT and had increased lipid peroxidation, and increased levels of MDA
and lipid profile.
Keywords: Leukemia, Oxidative stress, Antioxidants, Neoplastic Disorders
https://ijbpas.com/pdf/2019/April/MS_IJBPAS_2019_4695.pdf
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https://doi.org/10.31032/IJBPAS/2019/8.4.4695
