ABSTRACT

A library of eleven new conjugates of 1,2,3-triazole-hydrazone hybrid molecules have been synthesized using click chemistry. All the novel compounds were confirmed by different spectroscopic techniques and were evaluated for their antimicrobial activity. Most of the compounds were active against tested gram positive bacterial strains, whereas resistant towards two gram negative bacterial strains P.m and P.a. Compound 7 showed superior activity than the standard drug amoxicillin against E.c and K.p with zone of inhibition 30 mm and 32 mm respectively compared to standard drug amoxicillin which showed zone of inhibition 29 mm each at concentration of 200 ?g/disc. Compound 6 also showed promising activity with zone of inhibition 28 mm and 30 mm against E.c and K.p respectively comparable to standard drug. Five compounds showing significant activity were further evaluated for their minimum inhibition concentration (MIC). Compound 7 showed MIC 25 ?g/disk against E.c and K.p, compound 12 showed MIC 25 ?g/disk against E.c. Fungal strain Candida albicans was found to be resistant against most of the tested compounds. From the results it can be concluded halogen group present in the aromatic ring enhance the activity and need further work to synthesize more compounds to get some lead compound for drug candidate Keywords: 1,2,3-Triazole hydrazone hybrid, Phenyl azide, Click Chemistry, Antibacterial, Antifungal; Minimum inhibitory concentration

https://ijbpas.com/pdf/2019/January/MS_IJBPAS_2019_46061.pdf

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https://doi.org/10.31032/IJBPAS/2019/8.1.4606