ABSTRACT

H2-receptor antagonist is useful in a number of peptic disorders due to their capability of inhibiting all phases of gastric acid section. Cimetidine is one of the early members of this group. Levocetirizine belongs to non-sedative third generation antihistamine, improved as compare to its enantiomers cetirizine. In order to evaluate drug- drug interaction studies of levocetirizine with cimetidine, levocetirizine (5mg tablet) and cimetidine (200mg tablet) were introduced in dissolution medium together at the zero time (start of experiment). Samples of 5 ml were taken after every 15 minutes, keeping the volume of dissolution medium maintained. Absorbance maxima for both the drugs were obtained and the absorbance for each concentration was measured to the corresponding wavelength of the drugs. Levocetirizine and cimetidine interfere at each other’s wavelength; therefore, simultaneous equation is used to measure the percent availability of both the drugs in each other’s presence. Percent availability was 3684.74, 3563.14, 4199.80 and 1127.96 for levocetirizine and 3.22, 1.91, 0.00 and 0.00 for cimetidine in simulated gastric pH, pH 4, pH7.4 and pH9 respectively. On the basis of these studies, drug interaction of levocetirizine is proved with cimetidine. Keywords: Levocetirizine, cimetidine, drug interaction

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https://doi.org/10.31032/IJBPAS/2019/8.3.4659