ABSTRACT

Background: Rhazya stricta is an erect glabrous shrub widely distributed in Pakistan. The extract of its leaves has been prescribed in folk medicine in the treatment of various diseases. The present study aims to evaluate Rhazya stricta Decne leaves for its phytochemical and antibacterial properties. Study Site and Date: The study site was Dera Ismail Khan KPK Pakistan and sample was collected from federally administered tribal area, Mohmand Agency, Pakistan Methods: Plant was shade dried at room temperature for four weeks. Leaves (dried) of the plant were comminuted by using electric grinder with final dry weight of 750 gResults: It was observed that total phenolic content in relation to gallic acid equivalent (GAE) of extract was 189.9 ?g GAE/mg and in methanolic extract of Rhazya stricta Decne flavonoid with respect to quercitin equivalent (QE) was determined to be 27.7 ?g QE/mg. It was also noted that methanolic extract exhibited scavenging potential of 38.39 % and the total antioxidant capacity was found to be 273.80 ?g ascorbic acid equivalent/mg of extract. Conclusion: The plant showed highest activity against subtilis aureus while least against Escherichia coli, thus ensuring its phytochemical and therapeutic importance. Keywords: Rhazya stricta, Total phenolic contents, Phytochemicals, Antibacterial activity

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https://doi.org/10.31032/IJBPAS/2019/8.3.4649