ABSTRACT

The human inflammatory periodontal diseases are reported as amongst the most common of chronic diseases that affect adults. 69% of adults have early signs and only 5% are completely free from clinical signs of inflammation. The aim and objective of the present study was to evaluate the role of differential expression of lipid peroxidation and inflammatory markers in the failure of dental implant. Total 23 individuals were included in the study, among them 13 were diagnosed patients of dental implant failure and 10 were healthy controls having successful dental implant. Serum, saliva and urine samples were drawn from each individual. Various stress and inflammatory markers were performed through their respective protocols.Levels of stress profile including MDA, NO, 4-HNE and Isoprostanes were increased significantly in serum, saliva and urine of diseased patients as compared to healthy controls. Moreover levels of 8- OHdG, IL-6 and TNF-? were also raised significantly resulting in oxidative stress and inflammation that leads to failure of dental implant. Results of present study concluded that increased stress and inflammatory environment plays a key role in the failure of dental implant. Keywords: 8-OHdG, MDA, Dental Implant, 4-HNE, TNF-?

https://ijbpas.com/pdf/2019/February/MS_IJBPAS_2019_4657.pdf

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https://doi.org/10.31032/IJBPAS/2019/8.2.4657