ABSTRACT

Aim: The present study investigated the effect of supplementation of Sidr honey and vitamin A, C and E on penicillin-induced guinea pigs by lipid profile level. Methods: A total of Ninety-five adult male guinea pigs weighted 800-900g were divided into Twelve groups of five-ten guinea pigs each, and the experiment lasted for 30 consecutive days. Animals in group I served as control, animals in groups 2 were intraperitoneally (i.p.) injected with penicillin 50000IU/kg, animals in group 3-7 were administrated orally with Sidr honey 600mg/kg, vitamin A 10000IU/kg, vitamin C 100mg/kg, vitamin E 100mg/kg and vitamins A, C and E respectively, animals in group 8-12 in addition penicillin were orally administrated with Sidr honey, vitamin A, vitamin C, vitamin E and vitamin A,C and E respectively. Results: The result showed a significant increase in total cholesterol, triacylglycerol, LDLC and total lipid. And a significant decrease in HDLC in penicillin treated guinea pigs when compared to the control guinea pigs, but penicillin exposed and antioxidant vitamins A, C, E and Sidr honey treated groups produced significant (P

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https://doi.org/10.31032/IJBPAS/2019/8.2.4647