ABSTRACT

Bidentate azomethine ligands derived from condensation of anthranilic acid with vaniline (SL1), furfural (SL2), p-hydroxybenzaldehyde (SL3) and p-nitrobenzaldehyde (SL4) were synthesized. These ligands were used to prepare mononuclear metal complexes using Cu(II), Ni(II) and Zn(II) metal ions and formed square planar metal complexes with ligand to metal ratio of (2:1). Compounds were screened in vitro for antimicrobial activity using disc diffusion technique and were tested in vivo for molluscicidal activity against E. vermiculata l and snails. The ligands SL1 and SL3 were inactive (< 10 mm) against both bacterial types. SL2 and SL4 showed moderate activity (12.2-12.8 mm) against S. aureus and (14.8-15.6 mm) against S. pneumonia Gram-positive bacterial strains and were resistance against Gramnegative bacterial strains. SL2 and SL4 ligands showed moderate activity (11.6-16.4 mm) against C. albicans fungal strains too. While, the synthesized coordination compounds showed noticeable improvement in the activity against the C. albicans fungal strains, and the Gram-positive bacterial species S. pneumoniae and S. aureus strains under the same conditions. [Zn(SL2)2] and [Zn(SL4)2] were highly active against S. pneumonia bacterial species with zones of inhibition 20.4 mm and 30.2 mm respectively. Similarly, [Zn(SL2)2] and [Zn(SL4)2] were highly active against C. albicans with inhibition zones of 22.7 mm and 22.8 mm respectively. The minimum inhibition concentration (MIC) investigation was carried out and notable susceptibility was indicated for S. pneumonia bacterial strains with MIC values of 25?g/disc for the complex [Zn(SL4)2]. The molluscicidal activity tests showed highest activity at concentration of 0.45 mg/L for the complex [Zn(SL2)2]. Keywords: bidentate Schiffbase ligands, metal complexes, antifungal, antibacterial, molluscicidal activity

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https://doi.org/10.31032/IJBPAS/2019/8.2.4637