MOLECULAR DETECTION OF HUMAN HERPES VIRUS 6 (HHV-6) IN UNEXPLAINED HUMAN INFERTILITY Authors: Methaq Hussein Abbas
ABSTRACT
To decide whether HHV-6 may be a reason for infertility, a contextual analysis was led of 18
men and 10 women with unexplained essential fertility, somewhere around one past
pregnancy. HHV-6 DNA was distinguished in the peripheral blood mononuclear cells
(PBMC) from both infertile and fertile samples (12 and 14%, individually); Endometrial
epithelial cells from 4/10 (40%) infertile women were certain for HHV-6 DNA; this viral
DNA was not distinguished in endometrium of fertile women. At the point when put in
culture, endometrial epithelial cells delivered viral early and late proteins, recommending the
nearness of infectious virus. The outcomes propose that HHV-6 disease of the endometrium
triggers an unusual NK cell and cytokine profile, which thusly prompts a uterine domain that
isn't good with fertility. The outcomes should be affirmed with investigations of extra fertile
and infertile women. Semen tests were gathered from 18 men who were going to the
infertility facility at the Government General hospital Guntur, due to couple fertility issues.
The DNA of herpes viruses is every now and again distinguished in the semen of
asymptomatic fertile and infertile male patients. Additionally ponders are required to research
the job of herpes viruses in male/female factor infertility.
