ABSTRACT

It has been long described the major role of Propionibacterium acnes in the pathogenesis of acne vulgaris disease. There is increasing evidence that particularly persistent, relapsing and difficultto- treat infections caused by P. acnes are associated with the emergence of the drug resistant strains. The aim of this study is to evaluate the potential antimicrobial effects of Camel milk derived antimicrobial proteins and peptides against P. acnes by micro broth dilution assay. Here, we show that peptidoglycan recognition proteins PGRPs possess the strongest antimicrobial activity against P. acnes as compared to Lactoferrin and polyclonal anti-P. acnes antibodies. In addition, significant anti-inflammatory activity of PGRPs, and Lactoferrin was reported; however, less than the Anti-P. acnes antibody fraction. In conclusion, Camel derived immune proteins and peptides exert potent antimicrobial activity against P. acnes and could be considered as supportive and potent options in the treatment regimen of Acne vulgaris. Key words; Acne vulgaris, Innate immune proteins, Antimicrobial peptides, PGRP, and Anti-inflammatory effects

https://ijbpas.com/pdf/2019/January/MS_IJBPAS_2019_4623.pdf

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https://doi.org/10.31032/IJBPAS/2019/8.1.4623