ABSTRACT

This study synthesized gold nanoparticles using the citrate synthesis method and tested it for its fungicidal activity against Candida albicans, the causative fungus for Candidiasis. Three concentrations of 750, 500 and 250 ug/ml of synthesized gold nanoparticles (AuNP) were subjected to paper disc assay using corn meal agar against C. albicans. Synthesized AuNPs at 750 ug/ml concentration recorded the most effective antifungal activity against Candida albicans that even surpassed the inhibitory effects of the positive control, ketoconazole. The prevalent antifungal activity of the gold nanoparticles (AuNP) using the citrate synthesis method showed promising utilization as fungicidal mediator. It is confirmed that AuNPs synthesized using sodium citrate account for high antifungal effectiveness and displays a great potential in the development of drugs against C. albicans that are resistant to common antifungal drugs and causes treatment failures in candidiasis. Keywords: Gold nanoparticles, citrate synthesis, fungicidal activity, Candida albicans

https://ijbpas.com/pdf/2018/April/MS_IJBPAS_2018_4392.pdf

Download PDF