ABSTRACT

MicroRNAs (miRs) are highly conserved, endogenous non-coding RNAs among different species. miRs involve in the regulation of gene expression, hence it controls various cellular processes such as cell proliferation, apoptosis, and metastasis etc. Additionally in-spite of their physiological roles, miRs are deregulated in various pathological diseases including cancer. Metastasis is the primary reason of mortality in cancer patients. So the management of tumor cell invasion and metastasis play crucial role in cancer therapies. Many cellular mechanisms and molecular pathways have been identified in metastasis, which provide the basis of anti-metastatic drugs. miRs regulate timorous genes related to metastasis also. Recently, many studies have evidenced about the role of miRs in cancer metastasis and also revealed the concepts, that they target many genes, play a pivotal role in epithelial mesenchymal transition (EMT), which promotes invasive and motility properties of tumor cells. Herein, in this review, we have focused on recent findings of miRs in the regulation of EMT, migration, invasion and metastasis of cancer cells. Keywords: Metastasis; microRNA; Invasion; EMT

https://ijbpas.com/pdf/2018/April/MS_IJBPAS_2018_4355.pdf

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