ABSTRACT

The present work aims to study the pharmacokinetics parameters of vancomycin in Saudi patients, also to develop new equations for the prediction of these parameters from the population data based on their lab data. Data were coded individually, and analyzed as a single cohort or with stratification by the gender, age, and age group. The statistical software SPSS 22 was used for all analyses. 131 patients met the inclusion criteria and their data were analyzed in this study. The patients’ sample comprised 83 males (63.4%) and 48 females (36.6%). The mean age was 44.0±27.5 years (mean±SD) with an age range of 0.5-86 years. The mean weight of patients was 60.8±31.2 kg (range, 3-176 kg) and mean height 140.3±42.0 cm (range, 30-185 cm). The dosing rate of vancomycin in these patients was 11.74±89.24 mg/hr (range, 1.83-562.5 mg/hr, n=131). These is no statistically significant difference between newborn-infant group in kel (t-test, p=0.408). Although the half-life of vancomycin in newborns and infants was almost double its respective value in children, the difference was statistically insignificant (t-test, p=0.154). There is no significant difference in Vd between the two groups (newborn/infant

https://ijbpas.com/pdf/2018/March/MS_IJBPAS_2018_44151.pdf

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