ABSTRACT

Candida species are emerged as successful pathogens in both invasive and mucosal infections. Various virulence factors have contributed to their pathogenicity. The purpose of this prospective study was to isolate, speciate, and determine virulence factors of Candida species isolated from various clinical specimens. Total of 136Candida were isolated from various clinical specimens, identified up to species level by standard mycological techniques. All isolates were tested in vitro for biofilm formation (BF), proteinase (SAPs), phospholipase (PL), and haemolysin (HF) activity. One thirty six Candida, were isolated from different clinical samples. 71(52%) were C.albicans and 65(47%) non-albicans Candida (NAC) species. Biofilm formation was detected in 86(63%), proteinases activity (SAPs) in 90(66.2%), phospholipases (PL) activity in, 94((69.11%)and haemolysins (HF) activity was demonstrated in 123(90%). From the present study it can be established, that both C.albicans and NAC species are causing candidiasis and form biofilm, produce extracellular phospholipases, proteinases and haemolysins. Key words: Candida albicans, Haemolysins, NAC species, Phospholipases, Proteinases

https://ijbpas.com/pdf/2018/March/1520079739MS IJBPAS 2018 4397.pdf

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