ABSTRACT

Potential therapeutic approaches to protect (or) reverse gentamicin (GM) damage would be having very important clinical consequences of increasing the safety of the drug. Many literature reveal that the Mentha piperita found to be used in the traditional system of medicine. However nephroprotective activity of M.piperita has not been scientifically investigated. So, the present study was design to evaluate the protective effects of M.piperita on nephrotoxicity in rat model. Freshly prepared ethanolic and aqueous extracts of M.piperita (EMPet and AMPet) were orally administered to rats. The altered renal markers (Urea, uric acid, creatinine and BUN) after GM administered were normalized in extracts treated animals. The protective effects were confirmed by histopathology of renal tissues. In conclusion, the EMPet may emerge as a more putative nephroprotective agent than AMPet against nephrotoxicity. Further studies need to be undertaken in order to confirm these findings and its extrapolation in humans. Keywords: Peppermint, Mentha piperita, gentamicin, nephrotoxicity and renal markers

https://ijbpas.com/pdf/2018/March/1519963352MS IJBPAS 2018 4393.pdf

Download PDF